The cis-4-Amino-l-proline Residue as a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues

Endomorphin-2 (EM-2: Tyr-Pro-Phe-Phe-NH(2)) is an endogenous tetrapeptide that combines potency and efficacy with high affinity and selectivity toward the μ opioid receptor, the most responsible for analgesic effects in the central nervous system. The presence of the Pro(2) represents a crucial fact...

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Vydáno v:J Med Chem
Hlavní autoři: Mollica, Adriano, Pinnen, Francesco, Stefanucci, Azzurra, Feliciani, Federica, Campestre, Cristina, Mannina, Luisa, Sobolev, Anatoly P., Lucente, Gino, Davis, Peg, Lai, Josephine, Ma, Shou-Wu, Porreca, Frank, Hruby, Victor J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695669/
https://ncbi.nlm.nih.gov/pubmed/22394120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201402v
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