RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma

Dysregulation of MYC is frequently implicated in both early and late myeloma progression events, yet its therapeutic targeting has remained a challenge. Among key MYC downstream targets is ribosomal biogenesis, enabling increases in protein translational capacity necessary to support the growth and...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Lee, Hans C., Wang, Hua, Baladandayuthapani, Veerabhadran, Lin, Heather, He, Jin, Jones, Richard J., Kuiatse, Isere, Gu, Dongmin, Wang, Zhiqiang, Ma, Wencai, Lim, John, O’Brien, Sean, Keats, Jonathan, Yang, Jing, Davis, Richard E., Orlowski, Robert Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695568/
https://ncbi.nlm.nih.gov/pubmed/28369725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14525
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