Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics

[Image: see text] Accelerated proliferation of solid tumor and hematologic cancer cells is linked to accelerated transcription of rDNA by the RNA polymerase I (Pol I) enzyme to produce elevated levels of rRNA (rRNA). Indeed, upregulation of Pol I, frequently caused by mutational alterations among tu...

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Autors principals: Haddach, Mustapha, Schwaebe, Michael K., Michaux, Jerome, Nagasawa, Johnny, O'Brien, Sean E., Whitten, Jeffrey P., Pierre, Fabrice, Kerdoncuff, Pauline, Darjania, Levan, Stansfield, Ryan, Drygin, Denis, Anderes, Kenna, Proffitt, Chris, Bliesath, Josh, Siddiqui-Jain, Adam, Omori, May, Huser, Nanni, Rice, William G., Ryckman, David M.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025669/
https://ncbi.nlm.nih.gov/pubmed/24900516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300110s
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