Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor

[Image: see text] Structure–activity relationship analysis in a series of 3-(5-((2-oxoindolin-3-ylidene)methyl)furan-2-yl)amides identified compound 13, a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. Compound 13 exhibited in vitro synergy with chemotherapeutic...

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主要な著者: Haddach, Mustapha, Michaux, Jerome, Schwaebe, Michael K., Pierre, Fabrice, O’Brien, Sean E., Borsan, Cosmin, Tran, Joe, Raffaele, Nicholas, Ravula, Suchitra, Drygin, Denis, Siddiqui-Jain, Adam, Darjania, Levan, Stansfield, Ryan, Proffitt, Chris, Macalino, Diwata, Streiner, Nicole, Bliesath, Joshua, Omori, May, Whitten, Jeffrey P., Anderes, Kenna, Rice, William G., Ryckman, David M.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2011
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025662/
https://ncbi.nlm.nih.gov/pubmed/24900437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200259q
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