The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

Small molecules can affect many cellular processes. The disambiguation of these effects to identify the causative mechanisms of cell death is extremely challenging. This challenge impacts both clinical development and the interpretation of chemical genetic experiments. CX-5461 was developed as a sel...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bruno, Peter M., Lu, Mengrou, Dennis, Kady A., Inam, Haider, Moore, Connor J., Sheehe, John, Elledge, Stephen J., Hemann, Michael T., Pritchard, Justin R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049172/
https://ncbi.nlm.nih.gov/pubmed/32041867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921649117
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