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Lipid-Derived Electrophiles Mediate the Effects of Chemotherapeutic Topoisomerase I Poisons
Topoisomerase 1 (Top1) reversibly nicks chromosomal DNA to relax strain accumulated during transcription, replication, chromatin assembly and chromosome condensation. The Top1 poison camptothecin targets cancer cells by trapping the enzyme in the covalent complex, Top1(cc), tethered to cleaved DNA b...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8206239/ https://ncbi.nlm.nih.gov/pubmed/33352117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.11.011 |
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