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Preferential potentiation of topoisomerase I poison cytotoxicity by PARP inhibition in S phase
BACKGROUND: Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183837/ https://ncbi.nlm.nih.gov/pubmed/25003660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.378 |
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