Preferential potentiation of topoisomerase I poison cytotoxicity by PARP inhibition in S phase

BACKGROUND: Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S...

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Bibliografische gegevens
Hoofdauteurs: Znojek, P, Willmore, E, Curtin, N J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
Onderwerpen:
Translational Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183837/
https://ncbi.nlm.nih.gov/pubmed/25003660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.378
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