TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

The mechanistic target of rapamycin (mTOR) has a key role in the integration of various physiological stimuli to regulate several cell growth and metabolic pathways(1). mTOR primarily functions as a catalytic subunit in two structurally related but functionally distinct multi-component kinase comple...

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Vydáno v:Nature
Hlavní autoři: Wang, Bin, Jie, Zuliang, Joo, Donghyun, Ordureau, Alban, Liu, Pengda, Gan, Wenjian, Guo, Jianping, Zhang, Jinfang, North, Brian J., Dai, Xiangpeng, Cheng, Xuhong, Bian, Xiuwu, Zhang, Lingqiang, Harper, J. Wade, Sun, Shao-Cong, Wei, Wenyi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695540/
https://ncbi.nlm.nih.gov/pubmed/28489822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22344
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