Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow

Selectins mediate rolling of leukocytes by rapid formation and dissociation of selectin–ligand bonds, which are assumed to require high mechanical strength to prevent premature dissociation by the forces applied in shear flow. This assumption is based largely on the observation that increasing wall...

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Detalles Bibliográficos
Main Authors: Ramachandran, Vishwanath, Yago, Tadayuki, Epperson, Terry Kay, Kobzdej, Marcin M. A., Nollert, Matthias U., Cummings, Richard D., Zhu, Cheng, McEver, Rodger P.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC56933/
https://ncbi.nlm.nih.gov/pubmed/11481445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171248098
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