Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces.

In acute inflammatory responses, selectins mediate initial rolling of neutrophils (PMNs) along the endothelial surface. This is followed by tight adhesion that requires activation-dependent up-regulation of CD11/CD18 integrins on PMNs. For emigration to occur, the initial bonds that are established...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Lorant, D E, McEver, R P, McIntyre, T M, Moore, K L, Prescott, S M, Zimmerman, G A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185186/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7542276/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118018
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