Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow

Selectins mediate rolling of leukocytes by rapid formation and dissociation of selectin–ligand bonds, which are assumed to require high mechanical strength to prevent premature dissociation by the forces applied in shear flow. This assumption is based largely on the observation that increasing wall...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ramachandran, Vishwanath, Yago, Tadayuki, Epperson, Terry Kay, Kobzdej, Marcin M. A., Nollert, Matthias U., Cummings, Richard D., Zhu, Cheng, McEver, Rodger P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC56933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11481445/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.171248098
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