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Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow

Selectins mediate rolling of leukocytes by rapid formation and dissociation of selectin–ligand bonds, which are assumed to require high mechanical strength to prevent premature dissociation by the forces applied in shear flow. This assumption is based largely on the observation that increasing wall...

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Détails bibliographiques
Auteurs principaux: Ramachandran, Vishwanath, Yago, Tadayuki, Epperson, Terry Kay, Kobzdej, Marcin M. A., Nollert, Matthias U., Cummings, Richard D., Zhu, Cheng, McEver, Rodger P.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2001
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC56933/
https://ncbi.nlm.nih.gov/pubmed/11481445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171248098
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