IMMU-28. DEFINING MOLECULAR MECHANISMS OF RESISTANCE TO GLIOBLASTOMA (GBM) IMMUNITY USING A NOVEL CRISPR/CAS9 IN VIVO LOSS-OF-FUNCTION SCREENING PLATFORM

OBJECTIVE: Developing a high-throughput, in vivo, loss-of-function screening platform for GBM immune-escape mechanisms and identifying novel immuno-therapy targets. BACKGROUND: While recent success of cancer immunotherapy asserts the importance of immune-mediated tumor eradication, patients respond...

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Publicado no:Neuro Oncol
Main Authors: Neagu, Martha R, Speranza, Maria Carmela, Manguso, Robert T, Lawler, Sean E, Freeman, Gordon J, Doench, John, Sharpe, Arlene H, Haining, W Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693027/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.486
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