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EXTH-08. DISCOVERY OF CT-179: A SMALL MOLECULE INHIBITOR OF THE OLIG2 TRANSCRIPTION FACTOR WITH POTENT ANTI-TUMOUR ACTIVITY IN HIGH-GRADE GLIOMA
OLIG2 is a protein transcription factor (TF) expressed exclusively in progenitor cells in the brain and spinal cord during development and is re-expressed in most high-grade glioma (HGG) patients. Expression of OLIG2 drives the growth, invasiveness, and resistance to radiation of HGG cells and tumor...
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| Veröffentlicht in: | Neuro Oncol |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692999/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.304 |
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