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EAPH-16. DISCOVERY OF CT-179: A SMALL MOLECULE INHIBITOR OF THE OLIG2 TRANSCRIPTION FACTOR WITH POTENT ANTI-TUMOR IN PEDIATRIC BRAIN CANCER
OLIG2 is a protein transcription factor (TF) expressed exclusively in progenitor cells in the brain and spinal cord during development and is re-expressed in most adult and pediatric brain cancers. Expression of OLIG2 drives the growth, invasiveness, and resistance to radiation in brain cancer cells...
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Publicado no: | Neuro Oncol |
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Main Authors: | , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6011959/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.185 |
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