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EAPH-16. DISCOVERY OF CT-179: A SMALL MOLECULE INHIBITOR OF THE OLIG2 TRANSCRIPTION FACTOR WITH POTENT ANTI-TUMOR IN PEDIATRIC BRAIN CANCER

OLIG2 is a protein transcription factor (TF) expressed exclusively in progenitor cells in the brain and spinal cord during development and is re-expressed in most adult and pediatric brain cancers. Expression of OLIG2 drives the growth, invasiveness, and resistance to radiation in brain cancer cells...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Johns, Terrance, Greenall, Sameer, Chen, Charlotte, Day, Bryan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011959/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.185
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