PDTM-15. PLX51107, A NOVEL BROMODOMAIN INHIBITOR, WORKS SYNERGISTICALLY WITH AURORA-A KINASE INHIBITOR MLN8327 IN TREATING MYC-AMPLIFIED MEDULLOBLASTOMA

Group 3 medulloblastoma is a malignant childhood brain tumor with the worst prognosis among all subtypes of medulloblastoma. This subgroup has the highest frequency of MYC amplification. BRD4 is a member of the human bromodomain and extraterminal domain (BET) family of proteins and functions through...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Wadhwa, Elizabeth, Zhang, Jie, Powell, Ben, Van, Cassandra, Gustafson, Clay, Nicolaides, Theo
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692800/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.779
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