PDTM-34. COMBINED BET BROMODOMAIN AND CDK2 INHIBITION IN MYC-DRIVEN MEDULLOBLASTOMA

Misexpression of MYC genes (MYC and MYCN) occurs commonly in medulloblastoma (MB), the most frequent malignant childhood brain tumor. We previously showed that tumors are addicted to MYCN and that MYCN stabilization is required for MB development in mice (Swartling et al, Genes & Dev, 2010; Canc...

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Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Bolin, Sara, Borgenvik, Anna, Persson, Camilla, Sundström, Anders, Qi, Jun, Bradner, James, Weiss, William, Cho, Yoon-Jae, Weishaupt, Holger, Swartling, Fredrik
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
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Abstracts
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692361/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.797
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