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PDTM-15. PLX51107, A NOVEL BROMODOMAIN INHIBITOR, WORKS SYNERGISTICALLY WITH AURORA-A KINASE INHIBITOR MLN8327 IN TREATING MYC-AMPLIFIED MEDULLOBLASTOMA
Group 3 medulloblastoma is a malignant childhood brain tumor with the worst prognosis among all subtypes of medulloblastoma. This subgroup has the highest frequency of MYC amplification. BRD4 is a member of the human bromodomain and extraterminal domain (BET) family of proteins and functions through...
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| Publicado en: | Neuro Oncol |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692800/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.779 |
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