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Structural basis of human kinesin-8 function and inhibition

Kinesin motors play diverse roles in mitosis and are targets for antimitotic drugs. The clinical significance of these motors emphasizes the importance of understanding the molecular basis of their function. Equally important, investigations into the modes of inhibition of these motors provide cruci...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Locke, Julia, Joseph, Agnel Praveen, Peña, Alejandro, Möckel, Martin M., Mayer, Thomas U., Topf, Maya, Moores, Carolyn A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692573/
https://ncbi.nlm.nih.gov/pubmed/29078367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712169114
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