The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

MKLP2, a kinesin-6, has critical roles during the metaphase-anaphase transition and cytokinesis. Its motor domain contains conserved nucleotide binding motifs, but is divergent in sequence (~35% identity) and size (~40% larger) compared to other kinesins. Using cryo-electron microscopy and biophysic...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Atherton, Joseph, Yu, I-Mei, Cook, Alexander, Muretta, Joseph M, Joseph, Agnel, Major, Jennifer, Sourigues, Yannick, Clause, Jeffrey, Topf, Maya, Rosenfeld, Steven S, Houdusse, Anne, Moores, Carolyn A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602324/
https://ncbi.nlm.nih.gov/pubmed/28826477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27793
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