Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

Kinesins are a superfamily of microtubule-based ATP-powered motors, important for multiple, essential cellular functions. How microtubule binding stimulates their ATPase and controls force generation is not understood. To address this fundamental question, we visualized microtubule-bound kinesin-1 a...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Atherton, Joseph, Farabella, Irene, Yu, I-Mei, Rosenfeld, Steven S, Houdusse, Anne, Topf, Maya, Moores, Carolyn A
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2014
Soggetti:
Biophysics and Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358365/
https://ncbi.nlm.nih.gov/pubmed/25209998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03680
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