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The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

Kinesin-5 is required for forming the bipolar spindle during mitosis. Its motor domain, which contains nucleotide and microtubule binding sites and mechanical elements to generate force, has evolved distinct properties for its spindle-based functions. In this study, we report subnanometer resolution...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Goulet, Adeline, Behnke-Parks, William M., Sindelar, Charles V., Major, Jennifer, Rosenfeld, Steven S., Moores, Carolyn A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531780/
https://ncbi.nlm.nih.gov/pubmed/23135273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404228
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