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Loop L5 Acts as a Conformational Latch in the Mitotic Kinesin Eg5
All members of the kinesin superfamily of molecular motors contain an unusual structural motif consisting of an α-helix that is interrupted by a flexible loop, referred to as L5. We have examined the function of L5 in the mitotic kinesin Eg5 by combining site-directed mutagenesis of L5 with transien...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037637/ https://ncbi.nlm.nih.gov/pubmed/21148480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192930 |
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