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Structural basis of human kinesin-8 function and inhibition

Kinesin motors play diverse roles in mitosis and are targets for antimitotic drugs. The clinical significance of these motors emphasizes the importance of understanding the molecular basis of their function. Equally important, investigations into the modes of inhibition of these motors provide cruci...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Locke, Julia, Joseph, Agnel Praveen, Peña, Alejandro, Möckel, Martin M., Mayer, Thomas U., Topf, Maya, Moores, Carolyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692573/
https://ncbi.nlm.nih.gov/pubmed/29078367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712169114
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