DRES-10. THE DISTINCT CYTOTOXIC MECHANISM OF DIANHYDROGALACTITOL (VAL-083) OVERCOMES CHEMORESISTANCE AND PROVIDES NEW OPPORTUNITIES FOR COMBINATION THERAPY IN THE TREATMENT OF GLIOBLASTOMA

Treatment of glioblastoma (GBM) includes surgery and chemoradiation with temozolomide. Due to chemoresistance, nearly all tumors recur and 5-year survival is less than 3%. Various treatments, including anti-angiogenic treatment with bevacizumab, nitrosoureas and topoisomerase inhibitors, have failed...

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Publicado en:Neuro Oncol
Main Authors: Zhai, Beibei, Golebiewska, Anna, He, Guangan, Steino, Anne, Bacha, Jeffrey, Brown, Dennis, Niclou, Simone, Siddik, Zahid, Daugaard, Mads
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Abstracts
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692216/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.268
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