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Tolerance to Repeated Morphine Administration Is Associated with Increased Potency of Opioid Agonists
Tolerance to the pain-relieving effects of opiates limits their clinical use. Although morphine tolerance is associated with desensitization of μ-opioid receptors, the underlying cellular mechanisms are not understood. One problem with the desensitization hypothesis is that acute morphine does not r...
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| Publicado no: | Neuropsychopharmacology |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5688517/ https://ncbi.nlm.nih.gov/pubmed/18046309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.npp.1301634 |
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