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Analgesic tolerance to microinjection of the μ-opioid agonist DAMGO into the ventrolateral periaqueductal gray
Repeated administration of the relatively low-efficacy μ-opioid receptor agonist morphine induces tolerance to its antinociceptive effects. High-efficacy agonists such as D-Ala2NMePhe4,Gly-ol5 (DAMGO) have been shown to be less effective at producing tolerance, suggesting that different neural mecha...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1971241/ https://ncbi.nlm.nih.gov/pubmed/17445843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2007.03.002 |
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