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Chronic inflammatory pain prevents tolerance to the antinociceptive effect of morphine microinjected into the ventrolateral periaqueductal gray of the rat

The ventrolateral periaqueductal gray (vlPAG) contributes to morphine antinociception and tolerance. Chronic inflammatory pain causes changes within the PAG that are expected to enhance morphine tolerance. This hypothesis was tested by assessing antinociception and tolerance following repeated micro...

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Autors principals: Mehalick, Melissa L., Ingram, Susan L., Aicher, Sue, Morgan, Michael M
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876795/
https://ncbi.nlm.nih.gov/pubmed/24161274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2013.08.003
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