Tolerance to the Antinociceptive Effect of Morphine in the Absence of Short-Term Presynaptic Desensitization in Rat Periaqueductal Gray Neurons

Opioids activate the descending antinociceptive pathway from the ventrolateral periaqueductal gray (vlPAG) by both pre- and postsynaptic inhibition of tonically active GABAergic neurons (i.e., disinhibition). Previous research has shown that short-term desensitization of postsynaptic μ-opioid recept...

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Autori principali: Fyfe, Leon W., Cleary, Daniel R., Macey, Tara A., Morgan, Michael M., Ingram, Susan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2010
Soggetti:
Behavioral Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993552/
https://ncbi.nlm.nih.gov/pubmed/20739455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.172643
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