Extracellular Signal-Regulated Kinase 1/2 Activation Counteracts Morphine Tolerance in the Periaqueductal Gray of the Rat

Repeated administration of opioids produces long-lasting changes in μ-opioid receptor (MOR) signaling that underlie behavioral changes such as tolerance. Mitogen-activated protein kinase (MAPK) pathways, including MAPK extracellular signal-regulated kinases (ERK1/2), are modulated by opioids and are...

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Bibliographic Details
Main Authors: Macey, Tara A., Bobeck, Erin N., Hegarty, Deborah M., Aicher, Sue A., Ingram, Susan L., Morgan, Michael M.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2009
Subjects:
Behavioral Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775267/
https://ncbi.nlm.nih.gov/pubmed/19684256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.152157
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