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Analgesic tolerance to microinjection of the μ-opioid agonist DAMGO into the ventrolateral periaqueductal gray

Repeated administration of the relatively low-efficacy μ-opioid receptor agonist morphine induces tolerance to its antinociceptive effects. High-efficacy agonists such as D-Ala2NMePhe4,Gly-ol5 (DAMGO) have been shown to be less effective at producing tolerance, suggesting that different neural mecha...

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Détails bibliographiques
Auteurs principaux: Meyer, Paul J., Fossum, Erin N., Ingram, Susan L., Morgan, Michael M.
Format: Artigo
Langue:Inglês
Publié: 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1971241/
https://ncbi.nlm.nih.gov/pubmed/17445843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2007.03.002
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