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T cell-derived CD70 delivers an immune checkpoint function in inflammatory T cell responses

The CD27–CD70 pathway is known to provide a costimulatory signal with CD70 expressed on antigen-presenting cells while CD27 functioning on T cells. Although CD70 is also expressed on activated T cells, it remains unclear how T cell-derived CD70 affects T cell function. Therefore, we have assessed th...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: O'Neill, Rachel E., Du, Wei, Mohammadpour, Hemn, Alqassim, Emad, Qiu, Jingxin, Chen, George, McCarthy, Philip L., Lee, Kelvin P., Cao, Xuefang
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687300/
https://ncbi.nlm.nih.gov/pubmed/29046346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700380
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