Granzyme B Contributes to the Optimal Graft-Versus-Tumor Effect Mediated by Conventional CD4(+) T Cells

Granzyme B (GzmB) is a key cytotoxic molecule utilized by T cells to kill pathogen-infected cells or transformed tumor cells. Previous studies using allogeneic hematopoietic cell transplantation (allo-HCT) murine models showed that GzmB is required for CD8(+) T cells to cause graft-versus-host disea...

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Pubblicato in:J Immunol Res Ther
Autori principali: Du, Wei, Leigh, Nicholas D., Bian, Guanglin, Alqassim, Emad, O'Neill, Rachel E., Mei, Lin, Qiu, Jingxin, Liu, Hong, McCarthy, Philip L., Cao, Xuefang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070611/
https://ncbi.nlm.nih.gov/pubmed/27774524
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