Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease

Granzyme B (GzmB) has previously been shown to be critical for CD8(+) T cell-mediated graft-versus-host disease (GVHD) but dispensable for GVHD mediated by CD4(+) T cells. However, previous studies used high doses of CD4(+) T cells in MHC-mismatched models that caused rapid and lethal GVHD. Due to t...

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Veröffentlicht in:J Immunol
Hauptverfasser: Du, Wei, Leigh, Nicholas D., Bian, Guanglin, O’Neill, Rachel E., Mei, Lin, Qiu, Jingxin, Chen, George L., Hahn, Theresa, Liu, Hong, McCarthy, Philip L., Cao, Xuefang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610854/
https://ncbi.nlm.nih.gov/pubmed/26392464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500668
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