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Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

Matrix stiffness that is sensed by a cell or measured by a purely physical probe reflects the intrinsic elasticity of the matrix and also how thick or thin the matrix is. Here, mesenchymal stem cells (MSCs) and their nuclei spread in response to thickness-corrected matrix microelasticity, with incre...

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Publicado en:Mol Biol Cell
Autores principales: Buxboim, Amnon, Irianto, Jerome, Swift, Joe, Athirasala, Avathamsa, Shin, Jae-Won, Rehfeldt, Florian, Discher, Dennis E.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687034/
https://ncbi.nlm.nih.gov/pubmed/28931598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-06-0393
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