Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

Cell migration through solid tissue often involves large contortions of the nucleus, but biological significance is largely unclear. The nucleoskeletal protein lamin-A varies both within and between cell types and was shown here to contribute to cell sorting and survival in migration through constra...

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Autores principales: Harada, Takamasa, Swift, Joe, Irianto, Jerome, Shin, Jae-Won, Spinler, Kyle R., Athirasala, Avathamsa, Diegmiller, Rocky, Dingal, P.C. Dave P., Ivanovska, Irena L., Discher, Dennis E.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941057/
https://ncbi.nlm.nih.gov/pubmed/24567359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201308029
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