Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

Cell migration through solid tissue often involves large contortions of the nucleus, but biological significance is largely unclear. The nucleoskeletal protein lamin-A varies both within and between cell types and was shown here to contribute to cell sorting and survival in migration through constra...

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Bibliographic Details
Main Authors: Harada, Takamasa, Swift, Joe, Irianto, Jerome, Shin, Jae-Won, Spinler, Kyle R., Athirasala, Avathamsa, Diegmiller, Rocky, Dingal, P.C. Dave P., Ivanovska, Irena L., Discher, Dennis E.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941057/
https://ncbi.nlm.nih.gov/pubmed/24567359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201308029
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