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Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

Matrix stiffness that is sensed by a cell or measured by a purely physical probe reflects the intrinsic elasticity of the matrix and also how thick or thin the matrix is. Here, mesenchymal stem cells (MSCs) and their nuclei spread in response to thickness-corrected matrix microelasticity, with incre...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Buxboim, Amnon, Irianto, Jerome, Swift, Joe, Athirasala, Avathamsa, Shin, Jae-Won, Rehfeldt, Florian, Discher, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687034/
https://ncbi.nlm.nih.gov/pubmed/28931598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-06-0393
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