Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

Sirtuins are evolutionary conserved NAD(+)-dependent protein lysine deacylases. The seven human isoforms, Sirt1-7, regulate metabolism and stress responses and are considered therapeutic targets for aging-related diseases. Sirt4 locates to mitochondria and regulates fatty acid metabolism and apoptos...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Pannek, Martin, Simic, Zeljko, Fuszard, Matthew, Meleshin, Marat, Rotili, Dante, Mai, Antonello, Schutkowski, Mike, Steegborn, Clemens
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686155/
https://ncbi.nlm.nih.gov/pubmed/29138502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01701-2
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