Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight

The sirtuin enzymes are important regulatory deacylases in a variety of biochemical contexts and may therefore be potential therapeutic targets through either activation or inhibition by small molecules. Here, we describe the discovery of the most potent inhibitor of sirtuin 5 (SIRT5) reported to da...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Rajabi, Nima, Auth, Marina, Troelsen, Kathrin R., Pannek, Martin, Bhatt, Dhaval P., Fontenas, Martin, Hirschey, Matthew D., Steegborn, Clemens, Madsen, Andreas S., Olsen, Christian A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814306/
https://ncbi.nlm.nih.gov/pubmed/29044784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201709050
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