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Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin
[Image: see text] Sirtuins are NAD(+)-dependent protein lysine deacylases that are considered attractive drug targets for aging-related diseases. Sirt6 deacetylates, e.g., transcription factors and histone H3, and regulates metabolic processes and stress responses. It has been implicated in lifespan...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2020
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7667847/ https://ncbi.nlm.nih.gov/pubmed/33214841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00407 |
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