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Structures, Substrates, and Regulators of Mammalian Sirtuins – Opportunities and Challenges for Drug Development
Sirtuins are NAD(+)-dependent protein deacetylases regulating metabolism, stress responses, and aging processes. Mammalia have seven Sirtuin isoforms, Sirt1–7, which differ in their substrate specificities and subcellular localizations. The physiological functions of Sirtuins make them interesting t...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Research Foundation
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3275776/ https://ncbi.nlm.nih.gov/pubmed/22363286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00016 |
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