Structures, Substrates, and Regulators of Mammalian Sirtuins – Opportunities and Challenges for Drug Development

Sirtuins are NAD(+)-dependent protein deacetylases regulating metabolism, stress responses, and aging processes. Mammalia have seven Sirtuin isoforms, Sirt1–7, which differ in their substrate specificities and subcellular localizations. The physiological functions of Sirtuins make them interesting t...

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Autores principales: Moniot, Sébastien, Weyand, Michael, Steegborn, Clemens
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275776/
https://ncbi.nlm.nih.gov/pubmed/22363286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00016
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