Mechanism of activation for the sirtuin 6 protein deacylase

The histone deacetylase sirtuin 6 (SIRT6) regulates numerous biological functions, including transcriptional repression, DNA repair, and telomere maintenance. Recombinant SIRT6 displays catalytic efficiencies 2 orders of magnitude greater for long-chain deacylation than deacetylation against peptide...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Klein, Mark A., Liu, Can, Kuznetsov, Vyacheslav I., Feltenberger, John B., Tang, Weiping, Denu, John M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996886/
https://ncbi.nlm.nih.gov/pubmed/31822559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011285
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