A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions

Sirtuins are NAD(+) dependent lysine deacylases involved in many regulatory processes such as control of metabolic pathways, DNA repair and stress response. Modulators of sirtuin activity are required as tools for uncovering the biological function of these enzymes and as potential therapeutic agent...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Schuster, Sabine, Roessler, Claudia, Meleshin, Marat, Zimmermann, Philipp, Simic, Zeljko, Kambach, Christian, Schiene-Fischer, Cordelia, Steegborn, Clemens, Hottiger, Michael O., Schutkowski, Mike
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778124/
https://ncbi.nlm.nih.gov/pubmed/26940860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22643
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