Ex-527 inhibits Sirtuins by exploiting their unique NAD(+)-dependent deacetylation mechanism

Sirtuins are protein deacetylases regulating metabolism and stress responses. The seven human Sirtuins (Sirt1–7) are attractive drug targets, but Sirtuin inhibition mechanisms are mostly unidentified. We report the molecular mechanism of Sirtuin inhibition by 6-chloro-2,3,4,9-tetrahydro-1H-carbazole...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gertz, Melanie, Fischer, Frank, Nguyen, Giang Thi Tuyet, Lakshminarasimhan, Mahadevan, Schutkowski, Mike, Weyand, Michael, Steegborn, Clemens
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2013
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725051/
https://ncbi.nlm.nih.gov/pubmed/23840057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303628110
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