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Ex-527 inhibits Sirtuins by exploiting their unique NAD(+)-dependent deacetylation mechanism
Sirtuins are protein deacetylases regulating metabolism and stress responses. The seven human Sirtuins (Sirt1–7) are attractive drug targets, but Sirtuin inhibition mechanisms are mostly unidentified. We report the molecular mechanism of Sirtuin inhibition by 6-chloro-2,3,4,9-tetrahydro-1H-carbazole...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725051/ https://ncbi.nlm.nih.gov/pubmed/23840057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303628110 |
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