E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion

Altered processing of the Amyloid Precursor Protein (APP) is a well-recognized central pathogenic mechanism in Alzheimer's Disease (AD), and regulation of APP processing is a major focus of research in the AD field. However, how age-associated cellular and molecular changes contribute to change...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Benvegnù, Stefano, Wahle, Tina, Dotti, Carlos G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper: Gerotarget (Focus on Aging)
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685682/
https://ncbi.nlm.nih.gov/pubmed/29163761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20143
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