Resistance mechanisms to genetic suppression of mutant NRAS in melanoma

Targeted therapies have revolutionized cancer care but the development of resistance remains a challenge in the clinic. To identify rational targets for combination strategies, we used an established melanoma mouse model and selected for resistant tumors following genetic suppression of NRAS express...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Melanoma Res
Prif Awduron: Robinson, James P., Rebecca, Vito W., Kircher, David A., Silvis, Mark R., Smalley, Inna, Gibney, Geoffrey T., Lastwika, Kristin J., Chen, Guo, Davies, Michael A., Grossman, Douglas, Smalley, Keiran S.M., Holmen, Sheri L., VanBrocklin, Matthew W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683096/
https://ncbi.nlm.nih.gov/pubmed/29076949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0000000000000403
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