Resistance mechanisms to genetic suppression of mutant NRAS in melanoma

Targeted therapies have revolutionized cancer care but the development of resistance remains a challenge in the clinic. To identify rational targets for combination strategies, we used an established melanoma mouse model and selected for resistant tumors following genetic suppression of NRAS express...

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Foilsithe in:Melanoma Res
Main Authors: Robinson, James P., Rebecca, Vito W., Kircher, David A., Silvis, Mark R., Smalley, Inna, Gibney, Geoffrey T., Lastwika, Kristin J., Chen, Guo, Davies, Michael A., Grossman, Douglas, Smalley, Keiran S.M., Holmen, Sheri L., VanBrocklin, Matthew W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683096/
https://ncbi.nlm.nih.gov/pubmed/29076949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0000000000000403
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