Consequences of Depsipeptide Substitution on the ClpP Activation Activity of Antibacterial Acyldepsipeptides

[Image: see text] The acyldepsipeptide (ADEP) antibiotics operate through a clinically unexploited mechanism of action and thus have attracted attention from several antibacterial development groups. The ADEP scaffold is synthetically tractable, and deep-seated modifications have produced extremely...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Li, Yangxiong, Lavey, Nathan P., Coker, Jesse A., Knobbe, Jessica E., Truong, Dat C., Yu, Hongtao, Lin, Yu-Shan, Nimmo, Susan L., Duerfeldt, Adam S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2017
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682616/
https://ncbi.nlm.nih.gov/pubmed/29152050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00320
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