Optimization of Physicochemical Properties for 4-Anilinoquinazoline Inhibitors of Trypanosome Proliferation

Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. We previously reported the discovery of 2 (NEU-617), a small molecule with activity against T. brucei bloodstream proliferation. Further optimization of 2 to impro...

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Pubblicato in:Eur J Med Chem
Autori principali: Woodring, Jennifer L., Bachovchin, Kelly A., Brady, Kimberly G., Gallerstein, Mitchell F., Erath, Jessey, Tanghe, Scott, Leed, Susan E., Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J., Pollastri, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682201/
https://ncbi.nlm.nih.gov/pubmed/29049963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.10.007
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